Lakeshore Urology, PLC, Urology Services for Grand Haven, Muskegon, and Shelby, MI.
Lakeshore Urology, PLC

Lakeshore Urology

Serving Grand Haven, Muskegon, Shelby and the Lakeshore of West Michigan

Penile Injections for Erectile Dysfunction

Penile Injections for Erectile Dysfunction

Many men with erectile dysfunction find self injecting prostaglandin-E (PGE) works well for them.  This medication is also known as alprostadil. A tiny needle is used to inject a small amount of the medication into the shaft of the penis.  Within minutes, the medication causes the penis to get firm and erect long enough for enjoyable sex.

A generic form of the medication is available that has a limited shelf life and should be refrigerated.  A form of the medication that does not have to be refrigerated is available called Edex.

Pros:  Works very well in most men causing very firm erection.

Cons: Must inject each time, erections can be uncomfortable especially the first few times, generic version has limited shelf life.

How To Perform a Penile Injection for Erection

It is natural to be nervous about self injections, but you can become proficient with a little practice. 

Following are simple steps to properly give yourself an injection:

  • Wash your hands with soap and water.
  • Prepare the PGE using the directions provided.
  • You may stand or sit to give yourself the injection-- whatever position is easiest.
  • Identify the injection site on one side of the penis away from the top, bottom or head.  You should also avoid any visible veins.
  • Use alcohol (either an alcohol prep pad or cotton ball soaked in isopropyl alcohol) to cleanse the skin at the injection site.
  • Pull the penis to one side so the shaft skin is taut, resting it against your inner thigh stretched slightly toward your knee.  Avoid twisting or rotating the shaft.
  • Insert the needle directly into the side of the shaft (at a 90 degree angle).  Inject the prescribed amount of medication into the penis by pressing down on the plunger slowly over 4-5 seconds.
  • Retract the syringe, dispose of it safely and immediately place direct pressure on the injection site to prevent the small amount of bruising that can occur.
  • You may now stand up, massage the penis a bit, explore in foreplay.  You should gain an erection within 10-20 minutes.  It should last long enough for sex and probably longer.

  • The first few times you self inject, your penis may ache.  This will improve after repeated use.
  • You may feel a mild burning sensation during the injection, but not severe pain.  Stop the injection if this occurs.
  • Be sure to select an injection site on the side of your penis.  The medication will not work if injected elsewhere.
  • Rotate injection sites to minimize the risk of scarring.
  • Seek medical attention if the erection lasts more than 4-5 hours.
  • Generally, you should not use an injection more than once per day.

Seek Medical Attention If:   
  • You develop an erection lasting longer than 4-5 hours.   
  • You develop significant bleeding or bruising.   
  • You develop severe pain.   
  • You develop curvature of the penis or scarring.